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The authors found a statistical trend favoring amphotericin B deoxycholate with respect to clinical failure. Unfortunately, the individual trials included in the analysis and the meta-analysis were not powered to interpretive breakpoints place a strong emphasis on interpretation in the context of the delivered dose of the azole antifungal agent.

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In addition, the following adverse events have occurred during post-marketing experience.

Prothrombin times should be monitored carefully when fluconazole is used concomitantly with a coumarin anticoagulant. Concomitant use of fluconazole with nicoumalone a coumarin anticoagulant not commercially available in the US resulted in increased prothrombin time and intracranial hemorrhage in at least one patient.

Administration of fluconazole in individuals receiving tolbutamide, glyburide, or glipizide has resulted in increased AUCs and peak plasma concentrations and reduced metabolism of the order fluconazole online agent. Increased prothrombin time has been reported in patients receiving fluconazole concomitantly with a coumarin anticoagulant e.

Increased prothrombin times also have been reported when lower dosages of fluconazole 100 mg once daily were administered concomitantly with warfarin sodium. warfarin In one study in healthy adults receiving 200 mg of order fluconazole online daily or placebo, area under the prothrombin time versus time for a 7-day post-warfarin period curve for a single 15-mg warfarin dose increased by about 12% when concomitant fluconazole versus placebo were compared.

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Increased tacrolimus levels have been associated with nephrotoxicity. Dosage of orally administered tacrolimus should be decreased depending on tacrolimus concentration.

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    If you get any side effects, talk to your doctor or pharmacist. This includes any side effects not listed in this leaflet. A few people develop allergic reactions although serious allergic reactions are rare. ...

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    Maternal weight gain was impaired at all dose levels (approximately 0. Epidemiological studies suggest a potential risk of spontaneous abortion and congenital abnormalities in infants whose mothers were treated with 150 mg of fluconazole as a single or repeated dose in the first trimester, but these epidemiological studies have limitations and these findings have not been confirmed in controlled clinical trials. Fluconazole was administered orally to pregnant rabbits during organogenesis in two studies at doses of 5 mg/kg, 10 mg/kg, and 20 mg/kg and at 5 mg/kg, 25 mg/kg, and 75 mg/kg, respectively. ...

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    The effects of fluconazole on the pharmacokinetics of the sulfonylurea oral hypoglycemic agents tolbutamide, glipizide and glyburide were evaluated in three placebo-controlled studies in normal volunteers. (See CONTRAINDICATIONS and PRECAUTIONS. ...

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