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And in any event the maximum dose of sildenafil should under no circumstances exceed 25 mg within 48 hours. Co-administration of the HIV protease inhibitor saquinavir, a CYP3A4 inhibitor, at steady state (1200 mg three times a day) with sildenafil (100 mg single dose) resulted in a 140% increase in sildenafil Cmax and a 210% increase in sildenafil AUC. ildenafil had no effect on saquinavir pharmacokinetics (see section 4. Based on these pharmacokinetic results co-administration of sildenafil with ritonavir is not advised (see section 4. ...

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