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Significant improvements were observed in plasma glucose and insulin levels 45 Karela-Bitter melon Momordicacharantia MetforminClinicalSignificant decrease in serum glucose was observed in combination of fruit juice extract at half the normal dose of metformin 48 GlibenclamideClinicalSignificant decrease in serum glucose was observed in combination of fruit juice extract at half normal dose of glibenclamide 48 MetforminExperimentalFruit juice showed significant hypoglycemic effect in combination in normal, STZ- himalaya diabecon tablet alloxan-diabetic rats 49 51 Ginger Zingiber officinale GlibenclamideExperimentalCombination with ginger extract himalaya diabecon tablet blood glucose level greater than himalaya diabecon tablet alone 54 A sub-optimal dose of glibenclamide in combination with herb extract showed similar effects as a full therapeutic dose of glibenclamideMetforminExperimentalGinger reduces hyperglycaemia and improved renal dysfunction in diabetic rats at reduced metformin dose.

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