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Beta-blockers decrease arterial blood pressure by reducing cardiac output. Beta-blockers are used for treating hypertension, angina, myocardial infarction, arrhythmias and heart failure.

- to 5-mg rapid IV injections given at approximately 2- to 5-minute intervals up to a total of 15 mg over 10-15 minutes. The target resting heart rate with β-blocker therapy in patients with unstable angina is 50-60 bpm in the absence of dose-limiting adverse effects. Heart rate, blood pressure, and ECG should be monitored, and IV metoprolol therapy should be halted when therapeutic efficacy is achieved e.

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The prescribing information on metoprolol states that you should not stop taking metoprolol abruptly. Stopping metoprolol may cause your condition that you are treating to become worse and cause serious problems. Lori Poulin, PharmD A: Metoprolol Succinate ER Toprol XL rx metoprolol a medication that is used to treat various conditions of the heart rx metoprolol blood vessels such as high blood pressure.

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Although beta-adrenergic receptor blockade is useful in the treatment of angina, hypertension, and heart failure there are situations in which sympathetic stimulation is vital. Beta1-blocking effects in the range of 30-80% of the maximal effect approximately 8-23% reduction in exercise heart rate correspond to metoprolol plasma concentrations from 30-540 nmol/L.

The relationship metoprolol 50 mg dose plasma metoprolol levels and reduction in exercise heart rate is independent metoprolol 50 mg dose the pharmaceutical formulation. Using an Emax model, the maximum effect is a 30% reduction in exercise heart rate, which is attributed to beta1-blockade. The relative beta1-selectivity of metoprolol diminishes and blockade of beta2-adrenoceptors increases at plasma concentration above 300 nmol/L.

Metoprolol recommended dosage Thus, metoprolol can be used for the management of hypertension as initial monotherapy not usually preferred, but may be used for a compelling indication or as metoprolol recommended dosage component of a multiple-drug regimen.

If more than 3 drugs are required, other antihypertensive drug classes, including β-blockers, may be considered. If the blood pressure goal cannot be achieved with the above recommended strategies, consultation with a hypertension specialist should be considered.

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In general, administration of a beta-blocker should be withheld before dipyridamole testing, with careful monitoring of heart rate following the dipyridamole injection.

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