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Compensatory cardiac hypertrophy eventually leads to fibrosis and heart failure HF This mechanism may be promoted by the connective tissue growth factor CTGF which has been confirmed in an experimental model in rats with valvular HF9. In comparison with placebo physiological saline trimetazidine reduced collagen accumulation, CTGF expression in cardiac fibroblasts, nicotinamide adenine dinucleotide phosphate-oxidase NADPH oxidase levels, and ROS production9.

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FFA breakdown inhibition and glucose breakdown stimulationReduction in the amount of oxygen necessary for ATP productionReduction in the cellular accumulation of lactic acid and H When taken as directed, Vastarel MR will work differently than most anti-ischemic and anti-anginal drugs that reduce the workload on your heart.

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